Sawazaki I, Ribeiro M S, Mizuno L T et al.
The effect of toluidine blue and laser in combination has been studied by Sawazaki. Eight patients with inflammatory fibrous hyperplasias caused by ill-fitting dentures were selected for the study. Each hyperplasia was randomly divided into three areas. One was surgically removed without any treatment; one was treated by a 670 nm laser, 15 mW, 8 J/cm2 and then removed. The third part was dyed with TBO, and laser treated in the same way as part two. Mast cell degranulation in the control specimens was average 49´%, in the laser specimens 87% and in the combined TBO/laser specimens 88%. With these parameters the TBO did not have any additional effect.