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Low-energy laser irradiation promotes the survival and cell cycle entry of skeletal muscle satellite cells.

Shefer G, Partridge T A, Heslop L et al. Department of Animal Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. PMID: 11896194 [PubMed – indexed for MEDLINE] J Cell Science. 2002; 115: 1461-1469.   Low energy laser irradiation (LELI) has been shown to promote skeletal muscle cell activation and proliferation in primary cultures of satellite cells as well as in myogenic cell lines. Here, we have extended these studies to isolated myofibers. These constitute the minimum viable functional unit of the skeletal muscle, thus providing a close model of in vivo regeneration of muscle tissue. We show that LELI stimulates cell cycle entry and the accumulation of satellite cells around isolated single fibers grown under serum-free conditions and that these effects act synergistically with the addition of serum. Moreover, for the first time we show that LELI promotes the survival of fibers and their adjacent cells, as well as cultured myogenic cells, under serum-free conditions that normally lead to apoptosis. In both systems, expression of the anti-apoptotic protein Bcl-2 was markedly increased, whereas expression of the pro-apoptotic protein BAX was reduced. In culture, these changes were accompanied by a reduction in the expression of p53 and […]

Low level laser therapy for tendinopathy. Evidence of a dose-response pattern

Bjordal J M, Couppe´ C, Ljunggren E University of Bergen, Section of Physiotherapy Science, 5020 Bergen, NORVEGE Willemoes gade 61, 4.sal, 2100, Copenhagen, DANEMARK Physical Therapy Reviews (2001) 6: 91-99   To investigate whether low-level laser therapy can reduce pain from tendinopathy, the authors performed a review of randomized placebo-controlled trials with laser therapy for tendinopathy. Validity assessment of each trail was done according to predefined criteria for location-specific dosage and irradiation of the skin directly overlying the affected tendon. The literature search identified 78 randomised control trials of which 20 included tendinopathy. Seven trials were excluded for not meeting the validity criteria on treatment procedure and trial design. 12 of the remaining 13 trials investigated the effect of laser therapy for patients with subacute and chronic tendinopathy and provided a pooled mean effect of 21%. If results from only the nine trials adhering to assumed optimal treatment parameters wereincluded, the mean effect over placebo increased to 32%. Laser therapy can reduce pain in subacute and chronic tendinopathy if a valid treatment procedure and location-specific dose is used.

A comparative study of the effects of low laser radiation on mast cells in inflammatory fibrous hyperplasia colored or not colored by the toluidine blue.

Sawazaki I, Ribeiro M S, Mizuno L T et al. Laser Surg Med. Abstract issue 2002, abstract 301   The effect of toluidine blue and laser in combination has been studied by Sawazaki. Eight patients with inflammatory fibrous hyperplasias caused by ill-fitting dentures were selected for the study. Each hyperplasia was randomly divided into three areas. One was surgically removed without any treatment; one was treated by a 670 nm laser, 15 mW, 8 J/cm2 and then removed. The third part was dyed with TBO, and laser treated in the same way as part two. Mast cell degranulation in the control specimens was average 49´%, in the laser specimens 87% and in the combined TBO/laser specimens 88%. With these parameters the TBO did not have any additional effect.

LLLT is as well documented as NSAIDs and steroid injections for shoulder tendinitis/bursitis and epicondylaglia.

The Norwegian physiotherapist Jan M Bjordal published his thesis .Low level laser therapy in shoulder tendinitis/bursitis, epicondylalgia and ankle sprain. in 1997, at the Division of Physiotherapy Science, University of Bergen. It has also been published in Physical Therapy Reviews. 1998; 3: 121-132.   Here is the Conclusion of the thesis: .A systematic review has been performed on the effect of LLLT for three diagnoses. LLLT was evaluated on similar criteria for methodological assessments of trials as previously established for medical interventions. No evidence was found to indicate that randomized controlled trials on LLLT for tendinitis/bursitis of the shoulder, lateral epicondylalgia and ankle sprains were methodologically inferior to RCTs on medical interventions. The clinical effects of LLLT were found to be supported by scientific evidence regarding short (0-4 weeks) and medium term (<3 months) efficacy for subacute or chronic lateral epicondylitis, and short term efficacy (>3 months) for subacute or chronic lateral epicondylitis, and short term efficacy (> 3 months) for subacute or chronic shoulder tendinitis/bursitis. The evidence of effect from LLLT for acute ankle sprain in inconclusive, although there seems to be a slight tendency in favor of LLLT. Adverse effects of LLLT are rarely seen and only in […]

Clinical evaluation of the low intensity laser antialgic action of GaAIAs (wavelength=785 nm) in the treatment of the temporomandibular disorders

Sanseverino NTM, Sanseverino CAM, Ribeiro MS et al. The Journal of Laser Therapy MILLENNIUM EDITION • VOLUMES 12 & 13 Lasers in Medicine and Surgery (2002) Supplement 14, Atlanta, Georgia.   The improved outcome of laser therapy, if higher doses are given, is documented in the study by Sanseverino 10 patients with pain and limitation of movements of the jaw were treated by 785 nm GaAIAs laser, dose 45 J/cm2. The joint and tender points in the masticatory and otherwise involved muscles was applied three times per week during three weeks. A control group of 10 patients was given sham laser therapy. The evaluation was performed through subjective pain assessment and measurement of the movements of the jaw. There was a significant improvement in the laser group only.