Bjordal J M. A literature search identified 77 randomized clinical trials with LLLT, of which 18 included tendinitis. Three trials were excluded for lack of placebo control, of which one was comparative, another lacked patients with tendinitis in the treatment group, while the last unwittingly gave the placebo group active treatment. Four trials used too high power density or dose, and three did not expose the skin directly overlying the injured tendon. The remaining eight trials were included in a statistical pooling, where the mean effect of LLLT over placebo in tendinitis was calculated to 29.5% (19.5-39.0). LLLT with optimal treatment procedure/parameters can be effective in the treatment of tendinitis.
A. Barber 1, JE. Luger 1, A. Karpf 1 , Kh. Salame 2 , B. Shlomi 3, G. Kogan 3, M. Nissan 4, M. Alon 5, and S. Rochkind 2,6. 1Foot & Ankle Unit, Departments of Orthopedic Surgery “B”, Departments of 2Neurosurgery, 3Oral and Maxillofacial Surgery, and 5Rehabilitation, 6Division of Peripheral Nerve Reconstruction, Tel Aviv Sourasky Medical Center, Tel Aviv University; 4Ben Gurion University, Israel. The Journal of Laser Therapy. Vol.13. World Association of Laser Therapy. 2000. During the last decade, it was discovered that low-power laser irradiation has stimulatory effects on bone cell proliferation and gene expression. The purposes of this review are to analyze the effects of low- power laser irradiation on bone cells and bone fracture repair, to examine what has been done so far, and to explore the additional works needed in this area. The studies reviewed show how laser therapy can be used to enhance bone repair at cell and tissue levels. As noted by researchers, laser properties, the combinations of wavelength and energy dose need to be carefully chosen so as to yield bone stimulation.
Akai M, Usuba M, Maeshima T, Shirasaki Y, Yasuoka S. Department of Physical Therapy, Tsukuba College of Technology, Ibaraki, Japan. email@example.com PMID: 9365959 [PubMed – indexed for MEDLINE] Lasers Surg Med. 1997. 21(5): 480-4. The influence of low-level (810 nm)) laser on bone and cartilage during joint immobilization was examined with rats’ knee model. The hind limbs of 42 young Wistar rats were operated on in order to immobilize the knee joint. They were assigned to three groups 1 wk after operation; irradiance 3.9 W/cm2, 5.8 W/cm2, and sham treatment. After 6 times of treatment for another 2 wk both hind legs were prepared for 1) indentation of the articular surface of the knee (stiffness and loss tangent), and for 2) dual energy X-ray absorptiometry (bone mineral density) of the focused regions. The indentation test revealed preservation of articular cartilage stiffness with 3.9 and 5.8 W/cm2 therapy. Soft laser treatment may possibly prevent biomechanical changes by immobilization.
Shefer G, Partridge T A, Heslop L et al. Department of Animal Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. PMID: 11896194 [PubMed – indexed for MEDLINE] J Cell Science. 2002; 115: 1461-1469. Low energy laser irradiation (LELI) has been shown to promote skeletal muscle cell activation and proliferation in primary cultures of satellite cells as well as in myogenic cell lines. Here, we have extended these studies to isolated myofibers. These constitute the minimum viable functional unit of the skeletal muscle, thus providing a close model of in vivo regeneration of muscle tissue. We show that LELI stimulates cell cycle entry and the accumulation of satellite cells around isolated single fibers grown under serum-free conditions and that these effects act synergistically with the addition of serum. Moreover, for the first time we show that LELI promotes the survival of fibers and their adjacent cells, as well as cultured myogenic cells, under serum-free conditions that normally lead to apoptosis. In both systems, expression of the anti-apoptotic protein Bcl-2 was markedly increased, whereas expression of the pro-apoptotic protein BAX was reduced. In culture, these changes were accompanied by a reduction in the expression of p53 and […]
Bjordal J M, Couppe´ C, Ljunggren E University of Bergen, Section of Physiotherapy Science, 5020 Bergen, NORVEGE Willemoes gade 61, 4.sal, 2100, Copenhagen, DANEMARK Physical Therapy Reviews (2001) 6: 91-99 To investigate whether low-level laser therapy can reduce pain from tendinopathy, the authors performed a review of randomized placebo-controlled trials with laser therapy for tendinopathy. Validity assessment of each trail was done according to predefined criteria for location-specific dosage and irradiation of the skin directly overlying the affected tendon. The literature search identified 78 randomised control trials of which 20 included tendinopathy. Seven trials were excluded for not meeting the validity criteria on treatment procedure and trial design. 12 of the remaining 13 trials investigated the effect of laser therapy for patients with subacute and chronic tendinopathy and provided a pooled mean effect of 21%. If results from only the nine trials adhering to assumed optimal treatment parameters wereincluded, the mean effect over placebo increased to 32%. Laser therapy can reduce pain in subacute and chronic tendinopathy if a valid treatment procedure and location-specific dose is used.