Shefer G, Partridge T A, Heslop L et al. Department of Animal Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. PMID: 11896194 [PubMed – indexed for MEDLINE] J Cell Science. 2002; 115: 1461-1469. Low energy laser irradiation (LELI) has been shown to promote skeletal muscle cell activation and proliferation in primary cultures of satellite cells as well as in myogenic cell lines. Here, we have extended these studies to isolated myofibers. These constitute the minimum viable functional unit of the skeletal muscle, thus providing a close model of in vivo regeneration of muscle tissue. We show that LELI stimulates cell cycle entry and the accumulation of satellite cells around isolated single fibers grown under serum-free conditions and that these effects act synergistically with the addition of serum. Moreover, for the first time we show that LELI promotes the survival of fibers and their adjacent cells, as well as cultured myogenic cells, under serum-free conditions that normally lead to apoptosis. In both systems, expression of the anti-apoptotic protein Bcl-2 was markedly increased, whereas expression of the pro-apoptotic protein BAX was reduced. In culture, these changes were accompanied by a reduction in the expression of p53 and […]
Bjordal J M, Couppe´ C, Ljunggren E University of Bergen, Section of Physiotherapy Science, 5020 Bergen, NORVEGE Willemoes gade 61, 4.sal, 2100, Copenhagen, DANEMARK Physical Therapy Reviews (2001) 6: 91-99 To investigate whether low-level laser therapy can reduce pain from tendinopathy, the authors performed a review of randomized placebo-controlled trials with laser therapy for tendinopathy. Validity assessment of each trail was done according to predefined criteria for location-specific dosage and irradiation of the skin directly overlying the affected tendon. The literature search identified 78 randomised control trials of which 20 included tendinopathy. Seven trials were excluded for not meeting the validity criteria on treatment procedure and trial design. 12 of the remaining 13 trials investigated the effect of laser therapy for patients with subacute and chronic tendinopathy and provided a pooled mean effect of 21%. If results from only the nine trials adhering to assumed optimal treatment parameters wereincluded, the mean effect over placebo increased to 32%. Laser therapy can reduce pain in subacute and chronic tendinopathy if a valid treatment procedure and location-specific dose is used.
Junichiro Kubota M.D. Department of Plastic and Reconstructive Surgery, Kyorin University School of Medicine, Tokyo, Japan. Abstract from II Congress of the Internat. Assn for Laser and Sports Medicine, Rosario, Argentina, March 10-12, 2000 Flap survival with diode laser therapy: Skin flap or graft surgery are major procedures in plastic and reconstructive surgery. Skin flap necrosis has been a problem. The author reported on the enhanced blood flow following the low reactive laser therapy in skin flaps. The 830 nm diode laser (20 – 60 mw) irradiated flaps showed a greater perfusion, a greater number of blood vessels, and a higher rate of survival areas than the control flaps in the rat models and clinical cases. Improvement of wound healing with diode laser therapy: Diode laser therapy was indicated for traumatic skin ulcers from sport activities and traffic accidents which were resistant to conservative treatment. The diode laser system with a wavelength of 830 nm. and output power of 150or 1000mw in continuous wave was applied with the non-contact method to the area on the wound for one minute once a day every day during the treatment period. The diode laser was used successfully for the rapid enhanced healing […]
Lightwave of the Future The low-power laser for the treatment of carpal tunnel syndrome is safe, painless, and completely noninvasive.By John S. Soet REHAB MANAGEMENT; JANUARY/FEBRUARY 2005; PP. 24-30. It was the late 1960s. The Beatles were still the rage, the Vietnam War was in full swing, and Star Wars was a decade away. Theodore Maiman, utilizing a technique of concentrating and amplifying monochromatic light originally developed by two teams of researchers, produced a device known as LASER, light amplification by stimulated emission of radiation. Immediately, the term “ray gun” came to mind. The development of weapons-grade lasers became a priority. Because the beam could be concentrated to cut a minute surface area, surgical applications were also developed. But while governments and researchers were concentrating on military applications, a Hungarian physician named Endre Mester suspected that the laser might have a more humane application—the destruction of malignant tumors. Malignancies were traditionally treated with the cut/burn/poison strategy—surgery, chemotherapy, and radiation. If, indeed, the new addition to the scientific arsenal could destroy carcinomas with a minimum of damage to surrounding tissue, it would be an incredible breakthrough in cancer treatment. However, Mester concluded his research with good news and bad news. […]
Gur A, Karakoc M, Nas K, Cevik R, Sarac J, Demir E. Physical Medicine and Rehabilitation, School of Medicine, Dicle University, Diyarbakir, Turkey, TR Lasers in Medical Science (2002) 17(1):57-61. Low energy lasers are widely used to treat a variety of musculoskeletal conditions including fibromyalgia, despite the lack of scientific evidence to support its efficacy. A randomized, single-blind, placebo-controlled study was conducted to evaluate the efficacy of low-energy laser therapy in 40 female patients with fibromyalgia. Patients with fibromyalgia were randomly allocated to active (GaAs) laser or placebo laser treatment daily for two weeks except weekends. Both the laser and placebo laser groups were evaluated for the improvement in pain, number of tender points, skinfold tenderness, stiffness, sleep disturbance, fatigue, and muscular spasm. In both groups, significant improvements were achieved in all parameters (p<0.05) except sleep disturbance, fatigue and skinfold tenderness in the placebo laser group (p>0.05). It was found that there was no significant difference between the two groups with respect to all parameters before therapy whereas a significant difference was observed in parameters as pain, muscle spasm morning stiffness and tender point numbers in favour of laser group after therapy (p<0.05). None of the participants reported any […]